The market for Diffuse Large B-cell Lymphoma is skyrocketing and predicted to grow at a CAGR of 15% during forecast period 2020-2030, estimates DelveInsight

The market for Diffuse Large B-cell Lymphoma is skyrocketing and predicted to grow at a CAGR of 15% during forecast period 2020-2030, estimates DelveInsight

PR Newswire

LAS VEGAS, Jan. 12, 2021

The Diffuse Large B-cell Lymphoma (DLBCL) market is driven by factors such as Rising Incidence among Aging population, Increase in R&D, and CAR-T therapies approvals

LAS VEGAS, Jan. 12, 2021 /PRNewswire/ -- DelveInsight's "Diffuse Large B-cell Lymphoma Market Research Report" report delivers thorough comprehension of the Diffuse Large B-cell Lymphoma, historical and forecasted epidemiology along with the Diffuse Large B-cell Lymphoma market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan. The DLBCL market report provides analysis of current Diffuse Large B-cell Lymphoma treatment practice/algorithm, market drivers, market barriers and unmet medical needs.

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Diffuse Large B-cell Lymphoma Market Report's Few Key Highlights

Do you have any query regarding how ongoing trends will be impacting the DLBCL market? Get an a copy of DLBCL Market Sample Report

Diffuse Large B-cell Lymphoma (DLBCL) is the most common type of Non-Hodgkin Lymphoma (NHL) that affects B-lymphocytes. It develops when B-lymphocytes become abnormal. It is a mature B-cell neoplasm emanating from the germinal centre & post germinal centre B-cells.

Diffuse Large B-cell Lymphoma symptoms include painless, rapid swelling in the neck, underarms, or groin that is caused by enlarged lymph nodes. Other symptoms may comprise night sweats, fever, and unexplained weight loss. Patients may also notice fatigue, loss of appetite, shortness of breath, or pain. 

As per DelveInsight's estimates, total incident cases of DLBCL in the 7MM [the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), Japan] was observed to be 71,045 in 2020. The estimates are expected to increase due to the rising trend in the NHL incidence as well as DLBCL incidence in the 7MM, combined with underlying demographic changes in the respective markets. DLBCL most commonly affects middle-aged and older adults. The males appear to have a predisposition to DLBCL, which is why a higher percentage of incidence was observed in males as compared to females. 

The report offers a detailed historical, and forecasted analysis of Diffuse Large B-cell Lymphoma Epidemiology segmented as: 

Diffuse Large B-cell Lymphoma Market

Several options are available for B-cell Lymphoma treatment such as chemotherapy, radiation, and immunotherapy. Chemotherapy is the main way to treat most types of B-cell NHL. A combination of chemotherapy and the monoclonal antibody rituximab (Rituxan), with or without radiation therapy, can result in disease remission in a large number of patients with this form of lymphoma.

The most widely used frontline regimens used is the combination of R-CHOP [rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisone]. The R-CHOP is usually given every 3 weeks for a total of 6 cycles.

Despite these good results of R-CHOP, some patients may progress to the refractory disease. In these clinical settings, the standard therapeutic option is to commence high-dose therapy prior to either autologous or allogeneic stem cell transplantation (SCT). Patients who are not eligible for SCT or who fail after second-line therapy have a poor prognosis; the latest findings have unveiled that they could benefit from alternative salvage therapies.

Salvage therapies may also be utilized as a bridge to autologous or allogeneic SCT. There are several salvage therapies available, mostly involving rituximab in combination with standard antineoplastic agents, with the most frequently used combinations being R-ICE: rituximab plus ifosfamide, carboplatin, and etoposide, R-DHAP: rituximab plus cytosine, arabinoside, cisplatin, and dexamethasone, R-GDP: rituximab plus gemcitabine, dexamethasone, and cisplatin, R-ESHAP: rituximab plus etoposide, methylprednisolone, cytarabine, and cisplatin, R-GemOx: rituximab plus gemcitabine and oxaliplatin.

The FDA recently authorised Monjuvi(R) (tafasitamab-cxix) in Combination with Lenalidomide for the Treatment of Adult Patients with Relapsed or Refractory Diffuse Large B-cell Lymphoma (DLBCL). The Biologics License Application (BLA) for Monjuvi was granted Priority Review and approved under the FDA's Accelerated Approval program. MorphoSys and Incyte will co-commercialize Monjuvi in the United States. Incyte has exclusive commercialization rights outside the United States. 

The emergence of CD19-targeted CAR T-cell therapies into the DLBCL treatment paradigm, but, has led to high response rates and generated excitement within the third line of patients. Currently, in the US and EU5, both CAR T-cell products are given approval for use as third-line treatment in patients with relapsed/refractory DLBCL: axicabtagene ciloleucel (axi-cel; Yescarta) and tisagenlecleucel (Kymriah), while only Kymriah is available in the Japan market as of now. 

For more information about this report visit @ Diffuse Large B-cell Lymphoma Market Infographic

Final Thoughts 

In the last few years, the understanding of DLBCL biology has increased and has allowed a better understanding of the molecular mechanisms underlying the disease. The lymphomas incidence has increased, leading to drug development by pharmaceutical firms. Rituximab dominates the DLBCL market in front line settings, and there is still scope for other drugs in these settings with or without rituximab. Very high unmet need exists particularly for the patients with low ECOG (Performance status) or the ones not eligible for stem cell transplant.  Also, recently approved therapies in the relapsed/refractory setting extended the patient's life expectancy, thus providing larger window of opportunity for new treatment and the possibility of label expansions to other treatment lines and types.

However, rituximab based regimens are still the backbone of treatment of all B-cell NHL subtypes. Even though Rituximab dominates the DLBCL market in front line settings, and improved outcomes in patients with B-cell lymphomas, a significant number of patients are rituximab refractory at the time of relapse.

There are also no definite biomarkers available for progressive or the transformative form of the disease. 

Moreover, the expected entry of biosimilars and generics of rituximab, lenalidomide will plunge the market size of DLBCL. Furthermore, the cost of DLBCL treatment is exorbitant, and the upcoming treatment options like other CAR-T cell therapies, antibodies, and kinase inhibitors are also targeting on the higher side, and healthcare authorities will seek to restrict pricing and usage of the high-cost agent. On the other hand, the high cost of CAR-T cell therapies have also resulted in unique reimbursement scenarios across Europe. Durable long term results from CAR-T's are expected to persuade the reimbursement agencies in extending the benefit to a wider patient pool. Allogeneic cell therapies can also play a big role in overcoming the cost barrier of the current generation of cell therapies. We are excited to see the survival benefits in DLBCL patients and change in the current treatment paradigm with the approval of newer agents.

Diffuse Large B-cell Lymphoma Emerging Therapies

Scope of the Report

Table of Contents

1.        Key Insights

2.        Diffuse Large B-Cell Lymphoma Market Overview at a Glance

3.        DLBCL Executive Summary

4.        Organizations

5.        Diffuse Large B-Cell Lymphoma Disease Background and Overview

6.        DLBCL Epidemiology and Patient Population 

7.        Assumptions and Rationale: 7MM

7.1.      United States

7.2.      Germany

7.3.      France

7.4.      Italy

7.5.      Spain

7.6.      UK

7.7.      Japan

8.        DLBCL Current Treatment Practices

9.        Unmet Needs

10.     Diffuse Large B-Cell Lymphoma Marketed Drugs

10.1.   Tafasitamab: Morphosys/Incyte

10.2.   Yescarta: Gilead Life Sciences

10.3.   Kymriah: Novartis

10.4.   Selinexor: Karyopharm therapeutics

10.5.   Keytruda: Merck Sharp & Dohme

10.6.   Polatuzumab vedotin: Roche-Genentech/Chugai Pharmaceuticals

11.     Diffuse Large B-Cell Lymphoma Emerging Therapies

11.1. Lisocabtagene maraleucel: Bristol-Myers Squibb

11.2. Brentuximab Vedotin: Seattle Genetics/Takeda

11.3. Loncastuximab Tesirine: ADC Therapeutics

11.4. Treakisym: SymBio Pharmaceuticals

11.5. Enzastaurin (DB102): Denovo Biopharma

11.6.  Ublituximab + Umbralisib: TG Therapeutics

11.7. Blinatumomab: Amgen

11.8.  Aliqopa (Copanlisib/BAY 80-6946): Bayer

11.9.  Imbruvica (Ibrutinib): Janssen/Pharmacyclics (AbbVie Company)

11.10. Odronextamab (REGN1979): Regeneron Pharmaceuticals

11.11. Imfinzi (durvalumab): Celgene/Bristol Myers Squibb

11.12. Parsaclisib (INCB050465): Incyte Corporation

11.13. TC 110: TCR2 Therapeutics

11.14. DPX-Survivac: IMV, inc. & Merck

11.15. Acalabrutinib: AstraZeneca

11.16. AUTO3: Autolus Therapeutics

11.17. Obinutuzumab: Hoffmann-La Roche

11.18. CLR 131: Cellectar Bioscience

11.19. Debio1562: Debiopharm International 

12.     Diffuse Large B-Cell Lymphoma Market Outlook

13.     DLBCL Market Outlook by Country

13.1.   United States DLBCL Market Size

13.2.   Germany DLBCL Market Size

13.3.   France DLBCL Market Size

13.4.   Italy DLBCL Market Size

13.5.   Spain DLBCL Market Size

13.6.   UK DLBCL Market Size

13.7.   Japan DLBCL Market Size

14.     Diffuse Large B-Cell Lymphoma Market Drivers

15.     Diffuse Large B-Cell Lymphoma Market Barriers 

16.     SWOT Analysis

17.     Reimbursement and Diffuse Large B-Cell Lymphoma Market Access 

18.     Case studies

19.     KOL Views

20.     Appendix

21.     DelveInsight Capabilities

22.     Disclaimer

23.     About DelveInsight

Related Reports              

DelveInsight's "Diffuse Large B-cell Lymphoma Epidemiology Forecast 2030" report delivers an in-depth understanding of the disease, historical, and forecasted epidemiology of Diffuse Large B-cell Lymphoma in the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan.

"Diffuse Large B-cell Lymphoma Pipeline Insight, 2020" report by DelveInsight outlays comprehensive insights of present clinical development scenario and growth prospects across the Diffuse Large B-cell Lymphoma market.

DelveInsight' s B-Cell Non-Hodgkin Lymphoma - Market Insights, Epidemiology and Market Forecast - 2030 report provides a detailed overview of the disease and in depth understanding of historical and forecasted epidemiology.

DelveInsight' s Non-Hodgkin's Lymphoma (NHL) - Market Insights, Epidemiology and Market Forecast - 2030 report provides a detailed overview of the disease and in depth understanding of historical and forecasted epidemiology.


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