Postoperative Pain Market to Rising Steadily at a 7.93% CAGR Owing to Growing Number of Surgeries, During the Study Period [2018-2030], Says DelveInsight

Postoperative Pain Market to Rising Steadily at a 7.93% CAGR Owing to Growing Number of Surgeries, During the Study Period [2018-2030], Says DelveInsight

PR Newswire

LAS VEGAS, June 30, 2021

An increase in the number of surgeries, advancement in the current and emerging treatment options, and rise in the patient population proffer the impetus to Postoperative Pain Market Growth in the 7MM. 

LAS VEGAS, June 30, 2021 /PRNewswire/ -- DelveInsight's "Postoperative Pain Market" report provides a thorough comprehension of the Postoperative Pain historical and forecasted epidemiology and the Postoperative Pain market trends in the 7MM [the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan]. The Postoperative Pain market report also proffers an analysis of the current Postoperative Pain treatment algorithm/practice, market drivers, market barriers, and unmet medical needs. 


 Some of the necessary takeaways from the Postoperative Pain Market Research Report 

For further information on Market Impact by Therapies, visit: Postoperative Pain Drugs Market Analysis 

Postoperative Pain is defined as a condition of tissue injury together with muscle spasms after surgery. Postoperative Pain patients can be sub-segmented based on severity as mild, moderate, and severe.

As per DelveInsight's estimates, the Postoperative Pain incident cases were around 66,426,881 cases in the 7MM in 2020. Moreover, the United States has the highest percentage of the Postoperative Pain patient pool among these countries. 

The Postoperative Pain Market Analysis Report provides historical as well as forecasted epidemiological analysis segmented into: 

Get a complete epidemiological segmentation @ Postoperative Pain Epidemiological Analysis 

Postoperative Pain Treatment Market 

Postoperative Pain management aims to decline pain intensity, increase patient comfort, and improve postoperative outcomes. Pain-relieving analgesics include opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), and acetaminophen

Opioids are a large group of pain-relieving drugs that are utilized for alleviating pain in postoperative cases. These drugs majorly comprise fentanyl, hydromorphone, morphine, oxycodone, oxymorphone, and tramadol. In addition, the approved opioids include Zalviso, Olinvyk (Olinvo), Dzuveo/Dsuvia, Nucynta, DepoDur, and others. However, opioids have many dose-limiting side effects that range from bothersome to life-threatening.

Postoperative Pain Treatment Market Forecast and Recent Approvals 

Recently, in February 2021, FDA approved Posimir, a potential drug that is awaiting launch. Similar to Posimir, bupivacaine is the active ingredient in Pacira Biosciences' Exparel, also indicated for postsurgical pain relief. Being the clear market leader in branded post-surgical local anesthesia, Exparel (bupivacaine liposome injectable suspension) has generated impressive sales after its approval (effectively from the US). Posimir has been approved with limited labels, and thus, it is slightly evident that it might not give a head-to-head competition to Exparel. In addition, Xaracoll is an implant that is a unique, non-injectable, drug-device combination in the form of a fully bioresorbable collagen implant containing bupivacaine hydrochloride, providing postsurgical pain relief through the delivery of bupivacaine, a local anesthetic, at the surgical site. Although it is presently approved in the US, weak efficacy data might prevent it from becoming a substantial competitor in the pain management market. 

In 2018, local anesthetics grew around 20% in value, while opioids declined. Thus, it can be anticipated that local anesthetic demand will be very high in the Postoperative Pain market, and future, upcoming therapies can hold a tight market. Besides, the potential market for an effective long-acting local anesthetic working 72-h is enormous. 

Although Posimir and Xaracoll might not be significant threats to Exparel's market leadership, Heron Therapeutics' Zynrelef is ripe to compete with Exparel. Formerly known as HTX-011, it is one such drug with 72 h anesthetic action that is initially targeting many million procedures, including hospital inpatient, hospital outpatient, and ambulatory surgical centers (ASCs). The drug could be a threat to Pacira Biosciences' Exparel as recently the HTX-011 received a nod from US FDA, and soon it will be launched in the US market. 

While Zynrelef has received marketing approvals in the EU, Exparel has been in the Postoperative Pain market for more than a decade and has the edge over others. Despite that, Heron's candidate might stand out and become a direct competitor to Exparel in the future; several factors, including multiple advantages shown in its safety and efficacy data, might play a role. The drawbacks could be a limited use, which is only at the incision site and not in peripheral nerve blocks. HTX-011 has been tested in surgical settings and requires a surgeon to administer the drug, whereas Exparel has been adopted in expanding ASC settings. The popularity and use will depend on the product's cost after approval and availability all over. Nevertheless, HTX-011 approval has been full of controversy. Still, DelveInsight anticipates that it will cover a massive Postoperative Pain market by 2030

HTX-011 will face stiff competition in the US and EU-5: DelveInsight's Analyst Views. In the US, HTX-011 will compete with Marcaine (bupivacaine hydrochloride injection, solution, marketed by Pfizer Inc.) and generic forms of bupivacaine; Naropin (ropivacaine, marketed by Fresenius Kabi USA, LLC) and its generic forms; Exparel (bupivacaine liposome injectable suspension, marketed by Pacira BioSciences, Inc.); Xaracoll (bupivacaine HCl implant, marketed by Innocoll Pharmaceuticals Limited); Posimir (marketed by Durect Corporation); Anjeso (meloxicam injection, marketed by Baudax Bio, Inc.); Ofirmev (acetaminophen injection, marketed by Mallinckrodt Pharmaceuticals) and generic forms of IV acetaminophen; and potentially other products in development for Postoperative Pain management that reach the US market. Similarly, in EU-5, numerous generic local anesthetics and other nonopioids for postoperative pain management are available in the EU, and other products in development for postoperative pain management may also reach the EU market. For example, in November 2020, the EC granted marketing authorization for Exparel (bupivacaine liposome injectable suspension, marketed by Pacira BioSciences, Inc. in the US) for postsurgical analgesia. Pacira BioSciences, Inc. has indicated that it expects launching Exparel in the EU in the second half of 2021.

If approved, Cara Therapeutics IV CR845 would be competing within the overall acute postoperative pain market. However, the company expects to compete primarily with injectable mu-opioid analgesics, such as morphine, fentanyl, and hydromorphone. 

Scope of the Postoperative Pain Market Insight Report 

Request for a Webex demo of the report @ Postoperative Pain Therapeutics Market 

Table of Contents 


Postoperative Pain Report Introduction


Postoperative Pain Market Overview at a Glance


Postoperative Pain Market: Future Perspective


Executive Summary of Postoperative Pain


Postoperative Pain Disease Background and Overview


Postoperative Pain Epidemiology and Patient Population


The United States


EU5 Countries










The United Kingdom




Postoperative Pain Patient Journey


Postoperative Pain Marketed Drugs


Enanplus/Takudex (Dexketoprofen/Tramadol): Menarini Group/Guidotti Farma


Dsuvia/Dzuveo (Sufentanil): AcelRx Pharmaceuticals


Zalviso: AcelRx Pharmaceuticals


Olinvyk (Olinvo) (oliceridine): Trevena, Inc.


Zynrelef (HTX-011): Heron Therapeutics


Xaracoll: Innocoll Pharmaceuticals


Posimir (bupivacaine solution): DURECT Corporation


Exparel: Pacira Pharmaceuticals


Anjeso: Baudax Bio


Prolensa (bromfenac ophthalmic solution) 0.07%: Bausch & Lomb


Dextenza: Ocular Therapeutix


Inveltys: Kala Pharmaceuticals, Inc.


Penthrox: Medical Developments International Ltd (MVP)


Lotemax SM (loteprednol etabonate ophthalmic gel): Bausch & Lomb


Maxigesic: Hyloris Pharmaceuticals/AFT Pharmaceuticals


Postoperative Pain Emerging Therapies 


CR845/Difelikefalin: Cara Therapeutics


VVZ-149 Injections: Vivozon, Inc.


Tramadol IV: Avenue Therapeutics, Inc.


F14 (sustained-release celecoxib)/mdc-CWM (Celecoxib): Arthritis Innovation Corporation/MedinCell


Nefopam hydrochloride and paracetamol: Unither Pharmaceuticals


Co-crystal E-58425 (Tramadol/Celecoxib): Esteve Pharmaceuticals


APP13007: Formosa Pharmaceuticals


NTM-001 (Ketorolac Pre-Mixed Bag): Neumentum Pharmaceuticals


ACP-044: Acadia Pharmaceuticals Inc.


NVK-009 (Pregabalin and Acetaminophen): Nevakar, Inc.


TLC590: Taiwan Liposome Company (TLC)


MR-107A-01: Viatris Inc. (formerly known as Mylan Inc.)


TPU-006 (Dexmedetomidine Transdermal System (DMTS)): Teikoku Pharma USA, Inc. 


SAF312: Novartis Pharmaceuticals


OCS-01: Oculis


PRF110: PainReform LTD


Vocacapsaicin (CA-008): Concentric Analgesics


Nepafenac PPDS/Nepafenac Evolute: Mati Therapeutics Inc.


Postoperative Pain: 7MM Market Analysis


The United States Postoperative Pain Market Size


EU-5 Postoperative Pain Market Size


Germany Market Size


France Market Size


Italy Market Size


Spain Market Size


The United Kingdom Market Size


Japan Postoperative Pain Market Size


KOL Views


Postoperative Pain Market Drivers


Postoperative Pain Market Barriers


Postoperative Pain SWOT Analysis


Postoperative Pain Unmet Needs


Reimbursement and Postoperative Pain Market Access




DelveInsight Capabilities




About DelveInsight

Browse full report with detailed TOC with charts, figures, tables @ Postoperative Pain Diagnostics Market Report

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